Gal O, et al. - Researchers sought to investigate breast cancer characteristics, treatment, and survival in elderly women. Despite similar tumor characteristics, both age groups (65-75 years and >75 years) were different regarding treatment approach. Triple-negative (TN) subtype was the most aggressive disease in both age groups. They recommended physicians to be cautious to these findings and select treatment on a case-by-case basis.

Methods

• Researchers searched the database of a tertiary cancer center for all women aged ≥ 65 years who were diagnosed with early breast cancer in 2004-2007.
• They divided patients into 2 age groups: 65-75 years and > 75 years.
• Comparison of data on tumor, treatment, and outcome parameters was performed.

Results

• Three hundred ninety patients formed the cohort.
• Researchers observed more mastectomies but less axillary surgery or adjuvant systemic therapy in the older group.
• In the older group, median overall survival (OS) was 9.5 years and in the younger group, it was not reached; the 8-year disease-free survival rates were 85 and 88%, respectively (p=0.27).
• Findings revealed that both age and tumor subtype had an effect on OS and recurrence rates (p < 0.001 for OS; p=0.16 for recurrence).
• In women aged >75 years with triple-negative (TN) disease, worst outcome was noted.