Hadder B, et al. - Researchers here examine anesthesia work area reservoir isolation of Klebsiella, Acinetobacter, Pseudomonas, and Enterobacter spp (KAPE) pathogens. This retrospective analysis of a randomized, prospective, and observational study involving 3 academic medical centers reveals that for Acinetobacter spp, anesthesia provider hands are important reservoirs, whereas patient skin surfaces are key reservoirs for Enterobacter spp. A frequent transmission of Klebsiella, Acinetobacter, Pseudomonas, and Enterobacter pathogens is noted between operating room environments.