Bruno E, et al. - In view of significant morbidity and mortality associated with Herpes simplex virus (HSV) infection in the neonatal period, researchers searched for a standardized approach regarding when to initiate testing and treatment for HSV infection. Available research suggested strongly considering HSV infection in the febrile neonate if age is < 21 days, or if presenting with concerning clinical features. They recommend initiation of empiric treatment with high-dose acyclovir if testing is performed. Additional research is suggested to assess which cases mandate evaluation and treatment for HSV, and to better define treatment protocols.