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Does vitamin D supplementation improve ovarian reserve in women with diminished ovarian reserve and vitamin D deficiency: A before-and-after intervention study

BMC Endocrine Disorders Jun 25, 2021

Aramesh S, Alifarja T, Jannesar R, et al. - Researchers conducted the study for analyzing the effect of vitamin D supplementation on ovarian reserve in women with diminished ovarian reserve and vitamin D deficiency. The study is a before-and-after intervention study on women with a diminished ovarian reserve who were referred to the Shahid Mofteh Clinic in Yasuj, Iran. Eligible women were given vitamin D tablets at a weekly dose of 50,000 units for up to 3 months. At the end of 3 months, serum levels of vitamin D and anti-Mullerian hormone (AMH) were assessed. The current study's findings support a possible beneficial effect of vitamin D on increasing AMH expression by acting on the AMH gene promoter. As a result, vitamin D may raise AMH levels without affecting antral follicle count/ovarian reserve.

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