Tso LO, Leis L, Glina CG, et al. - Usually concerns have been raised by women undergoing assisted reproductive treatment regarding the side effects caused by high doses of gonadotropin. Researchers herein investigated if controlled ovarian stimulation is associated with an increase in the weight of women undergoing IVF treatment. In this retrospective cohort study, they assessed 734 women undergoing IVF treatment who had body weight measured on the day of ovarian stimulation starting (basal-weight) and on the hCG trigger day (hCG-weight). They paired and compared the basal-weight and hCG-weight and demonstrated a statistically significant weight gain from basal to hCG-weight of a mean of 387.7±720.4 grams. The weight gain is possibly linked with edema occurrence and is clinically irrelevant despite the statistical significance. Resolution of this weight gain will probably occur in some days after oocytes retrieval. There was a small “weight gain” that was noted to be associated with the number of oocytes retrieved regardless of protocol and medication used in the ovarian stimulation.