Chamberlain JA, Dugué PA, Bassett JK, et al. - By performing this prospective case–control analysis nested within the Melbourne Collaborative Cohort Study, researchers investigated the association between DNA methylation in peripheral blood and the risk of gastric cancer. They prepared genomic DNA from blood samples obtained a median of 12 years prior to diagnosis for cases (N = 168). They matched cases with controls (N = 163) by sex, year of birth, country of birth, and blood sample type employing incidence density sampling. Experts identified no proof of links with gastric cancer risk for individual CpGs or differentially methylated regions. No evidence of link was noted with global measures of methylation. No evidence for a prospective link of blood DNA methylation with gastric cancer risk was found in this study.