Friedlaender E, et al. - Using the Pediatric Health Information System database, researchers conducted this retrospective cohort study to characterize analgesia administration between neurotypical (NT) individuals and those with autism spectrum disorder (ASD) diagnosed with appendicitis or long bone fractures in the Emergency Department (ED), as well as to compare the rates of complicated appendicitis as a proxy for delayed diagnosis between the groups. Participants in the study were children (aged 6 to 18 years) with ASD and with appendicitis or fracture ED visit from 2004 to 2015 matched with demographically similar NT children. Between 2004 and 2015, 126,412 children with appendicitis were identified as well as 392,151 children with long bone fractures. According to results, there was no significant difference in receipt of analgesia between ASD and NT peers populations. Findings revealed that children with ASD have increased rates of complex appendicitis, possibly implying limited access to care or provider difficulty in assessing this patient population.