Zur D, Iglicki M, Sala-Puigdollers A, et al. - In this multicentre, retrospective study, researchers examined disorganization of retinal inner layers (DRIL) as a biomarker in eyes with diabetic macular oedema (DME) treated by intravitreal dexamethasone (DEX) implant. This investigation involving eyes with DME treated with DEX implant and follow-up of 12 months after the first injection. Optical coherence tomography scans were assessed for the presence of DRIL and other structural features. The correlation between baseline DRIL and outcomes were analyzed after treatment with DEX and the change in DRIL. It included a total of 177 eyes. At baseline, patients without DRIL acquired considerably more vision and enjoyed higher central subfield thickness decrease over 12 months. This is the first research to demonstrate the ability of DEX implant to improve DRIL. Baseline patients without DRIL have a positive result. In DME treated with DEX implant, DRIL can serve as a solid biomarker.