Lu M, Goodwin B, Vera-Llonch M, et al. - In patients with eosinophilic esophagitis (EoE) and matched controls without EoE, researchers sought to examine disease burden and treatment patterns in patients with EoE and compared healthcare resource use (HCRU) in this US-based, retrospective claims study. From the Truven Health MarketScan Research databases (January 2008 to September 2016), patients with a diagnosis of EoE and ≥ 12 months of prediagnosis data were identified and followed up from the diagnosis date until termination of eligibility for a health plan. Gastroesophageal reflux disease was the most common prediagnosis condition (34.6%) among the 23,003 patients with EoE (mean age: 34.3 years; 64.8% male). The most common off-label, first-line treatments were proton pump inhibitor monotherapy (52.8%) and topical corticosteroid monotherapy (21.5%). Compared to matched controls, patients with EoE, inpatient admissions and outpatient and emergency room visits were more likely. In the US, patients with EoE face a high burden of illness both before and after diagnosis, requiring substantial HCRU. The results reinforce the unmet need for effective monitoring of symptoms linked to EoE.