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Discontinuous stereotactic body radiotherapy schedule increases overall survival in early-stage non-small cell lung cancer

Lung Cancer May 28, 2021

Duvergé L, Bondiau PY, Claude L, et al. - Researchers focused on the influence of a continuous vs discontinuous stereotactic body radiotherapy (SBRT) schedule on local control (LC) as well as overall survival (OS) in patients suffering from non-small cell lung cancer (NSCLC). They retrospectively examined consecutive NSCLC stage I cases (475) managed with SBRT in four centers. Depending on the ratio between the treatment duration (TD) and number of fractions (n), patients were split into two categories: continuous schedule (CS) (TD ≤ 1.6n; 239 patients) and discontinuous schedule (DS) (TD > 1.6n; 236 patients). According to findings, significantly improved LC and OS were observed in relation to DS in early-stage NSCLC patients managed with SBRT.

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