Meisel SR, Kleiner‐Shochat M, Abu‐Fanne R, et al. - In patients with ST‐segment–elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PPCI), it is essential to shorten the pain‐to‐balloon (P2B) and door‐to‐balloon (D2B) intervals in order to limit myocardial damage. Researchers examined if and how direct admission of PPCI‐treated patients with STEMI to the catheterization laboratory, bypassing the emergency department, affects reperfusion and prognosis. Among 4,839 consecutive PPCI‐treated patients with STEMI included in the ACSIS (Acute Coronary Syndrome in Israel Survey), 1,174 were admitted directly and 3,665 via the emergency department. By shortening P2B and D2B intervals considerably, direct admission of PPCI‐treated patients with STEMI reduced mortality. However, mortality was affected by P2B, but not by D2B. It appears that the D2B interval has attained its limit of effect. Hence, they emphasize making all efforts to shorten P2B by educating the public to activate early the emergency medical services to bypass the emergency department and facilitate timely PPCI for the best outcome.