Zhao S, Li X, Wu W, et al. - Digoxin definitely exerts a preventive effect against prostate cancer (PCa) development in men but was linked with a significantly increased risk of prostate cancer-specific mortality.

• A systematic review and pooled analysis was conducted.

• Four electronic databases were systematically explored for eligible studies.

• Ten clinical studies including 108,444 participants (15,835 persons were digoxin users) were analyzed.

• A correlation of digoxin with a significantly reduced PCa risk (adjusted RR = 0.892), vs nonusers, was revealed in pooled results from 6 included studies.

• A significant correlation of digoxin with higher prostate cancer-specific mortality, vs the controls (adjusted hazard ratio = 1.142), was unveiled by synthetic results of 4 eligible studies.

• There appeared no statistical heterogeneity.