Kerr K, et al. - Researchers analyzed current evidence to assess the potential for differential methylation as a diagnostic biomarker for rare renal diseases, via this comprehensive systematic review. Data published before September 2018 were extracted from electronic databases MEDLINE, EMBASE, PubMed, Cochrane Library, alongside grey literature from GreyLit and OpenGrey databases. Overall 13 full-text articles were included, with glomerular disease, IgA nephropathy, Autosomal Dominant Polycystic Kidney Disease, rare causes of proteinuria, congenital renal agenesis, and membranous nephropathy being the diseases analysed for differential methylation. Findings highlighted the potential of differential methylation for improving molecular characterization of several rare renal diseases. In order to improve research quality, it is essential that methylation is further explored following a standardized reporting structure.