Jensen CE, et al. - Considering the prior reports demonstrating inferior outcomes for patients with right-sided colorectal cancer (CRC) compared to patients with left-sided disease, as well as differences in treatment response based on disease sidedness, researchers compared mutation prevalence between right- (cecum to splenic flexure) and left-sided (descending colon to rectum) CRC among 38 genes in a retrospective review of next-generation sequencing data of CRC samples obtained in routine clinical practice at a single academic medical center. The results obtained in this study for overall survival in left-sided colorectal cancer (LCC) vs right-sided colon cancer (RCC) were consistent with those seen in prior studies. Patients with right-sided CRC had a higher prevalence of BRAF and CTNNB1 mutations that could be associated with the mechanisms underlying the discrepant outcomes and treatment responses between RCC and LCC.