Hajelssedig OE, Zorron Cheng Tao Pu L, Thompson JY, et al. - Researchers conducted this systematic review and meta‐analysis to assess narrow-band imaging (NBI)-guided targeted biopsies’ diagnostic accuracy for detecting dysplasia in patients undergoing endoscopic Barrett’s esophagus (BE) surveillance compared to the widely used Seattle protocol. Until 2018, the Cochrane DTA Register, MEDLINE/PubMed, EMBASE, OpenGrey, and bibliographies of identified papers were searched. Using a random-effects model, data on sensitivity, specificity, and predictive values were pooled and analyzed. Six studies with a total of 493 participants were chosen from a pool of 9,528 articles for quantitative synthesis. NBI-targeted biopsy revealed high diagnostic accuracy in the detection of dysplasia in BE with a sensitivity of 76%, specificity of 99%, the positive predictive value of 97%, and negative predictive value of 84% for detection of all grades of dysplasia. Data reported that the receiver-operating curve for NBI model performance in detecting all dysplasia was 0.8550. NBI-guided biopsy showed high diagnostic accuracy and may be a viable alternative to random biopsies during endoscopic surveillance for dysplasia in BE.