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Diagnostic accuracy of fibrosis tests in children with non‐alcoholic fatty liver disease: A systematic review

Liver International May 16, 2021

Draijer LG, van Oosterhout JPM, Vali Y, et al. - This is the first systematic review assessing the diagnostic accuracy of non‐invasive methods for staging liver fibrosis in children with non‐alcoholic fatty liver disease (NAFLD). Twenty studies were included, totalling 1,787 NAFLD patients, and evaluated three prediction scores, five simple biomarkers, two combined biomarkers, and six imaging techniques. The FibroScan, ELF test, and ultrasound elastography provided the most consistent data with high accuracy. The accuracy and clinical utility of non‐invasive fibrosis tests in children with NAFLD remains unknown due to a lack of validation. Because the studies were only conducted in tertiary care settings, the accuracy data cannot be directly translated to screening populations.

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