Diabetes mellitus is not independently associated with mortality in elderly patients with ST-segment elevation myocardial infarction. Insights from the Codi Infart registry
Coronary Artery Disease Dec 18, 2019
Gual M, Ariza-Solé A, Formiga F, et al. - Given the predictive value of diabetes mellitus for poorer outcomes in patients with the acute coronary syndrome, researchers sought to determine the magnitude of this association in patients at older ages. The Codi Infart database provided data of 12,792 cases for this work; of these 3,023 (23.6%) were aged at least 75 years. Diabetes mellitus was evident in about 20% of the patients indicating the prior presence of diabetes mellitus in a significant proportion of these nonselected patients with ST-segment elevation myocardial infarction. Higher prevalence of comorbidities, higher proportion of heart failure at admission, a more extensive coronary artery disease and significant delay to reperfusion were evident in patients aged at least 75 years. They observed an association of diabetes mellitus with higher 30-day mortality both in young as well as in elderly patients. After adjusting for potential confounders, young patients, but not the elderly, exhibited this association significantly. Likewise, diabetes mellitus and 1-year mortality were crudely associated with each other in both groups. However, after adjusting for potential confounders, younger patients, but not the elderly exhibited this association significantly. The association between diabetes mellitus and outcomes is different according to age.
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