Hughes CG, Mailloux PT, Devlin JW, et al. - Given that targeting light sedation with dexmedetomidine or propofol for adults undergoing mechanical ventilation is currently suggested by guidelines but these sedatives differ in terms of arousability, immunity, and inflammation, so, if they impact results differentially in mechanically ventilated adults with sepsis receiving light sedation was inquired in this multicenter, double-blind trial. Randomization of mechanically ventilated adults with sepsis was done to dexmedetomidine or propofol, with doses adjusted by bedside nurses to attain target sedation aims decided by clinicians as per the Richmond Agitation–Sedation Scale. In terms of the number of days alive without delirium or coma, ventilator-free days, death at 90 days, or Telephone Interview for Cognitive Status questionnaire score at 6 months, there were no differences between dexmedetomidine and propofol. Both groups had similar safety endpoints. Overall, it was clear that outcomes did not differ between dexmedetomidine and propofol groups in this study population of mechanically ventilated adults with sepsis who were being treated with recommended light-sedation approaches.