Zorrilla-Vaca A, et al. - Researchers performed a comparison of the effectiveness of intravenous vs perineural dexamethasone on the effectiveness and safety of peripheral nerve blocks (PNBs). Findings confirmed the superiority of perineurally administered dexamethasone in terms of analgesic effects as compared with its intravenous injection. In addition, the study implicitly supported the hypothesis of local interaction between dexamethasone and the nerve as one of the pain modulation mechanisms of dexamethasone, because systemic absorption alone could not explain the superior quality of PNBs.