He Y, et al. - Since HBsAg-positive gastric cancer (GC), one of the most common malignancies and ranks the second leading cause of cancer death worldwide, patients are a heterogeneous group, and it is not possible to accurately predict the overall survival (OS) in these patients, a prognostic nomogram was developed and validated by researchers using widely available clinical and laboratory pretreatment data to improve the ability to predict HBsAg-positive GC. In addition, a test was performed to determine whether this model provides a more accurate prediction of prognosis when compared with TNM staging system. By univariate and multivariate Cox hazard analysis, factors in the nomogram were identified. Age, tumor stage, distant metastases, gamma-glutamyl transpeptidase (GGT) and alkaline phosphatase (ALP) were significant predictors. Using five characteristics of pretreatment, this nomogram improves OS prediction in patients with HBsAg-positive gastric cancer. It represents an improvement over the current TNM stage in prognosis. Additional validation with data from other institutions is required to generalize the use of this nomogram in other groups.