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Development and validation of a novel mitophagy-related gene prognostic signature for hepatocellular carcinoma based on immunoscore classification of tumor

Journal of Oncology Oct 28, 2021

Chen H, Wang J, Zeng R, et al. - Emerging evidence suggests an important role of mitophagy in the progression of hepatocellular carcinoma (HCC). Researchers herein investigated the correlation between mitophagy-related genes (MRGs) and HCC patients’ prognosis.

  • HCC patients from the TCGA cohort were categorized into two immune score groups according to the median immunoscore, while identifying 39 differential expression MRGs.

  • Eighteen survival-associated MRGs were screened out by using univariate analysis, and then, a prognosis model was constructed by applying the least absolute shrinkage and selection operator (LASSO) analysis; the model consisted of 9 MRGs (ATG7, ATG9A, BNIP3L, GABARAPL1, HTRA2, MAP1LC3B2, TFE3, TIGAR, and TOMM70).

  • In the prognostic model, significantly different overall survival was recorded in the high and low-risk groups.

  • The risk score was identified to be the independent factor for predicting the HCC patients’ prognosis. 

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