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Determinants and prognostic significance of serial right heart function changes in patients with cardiac amyloidosis

Canadian Journal of Cardiology Mar 12, 2020

Fine NM, et al. - Since right heart function represents a crucial prognostic determinant in cardiac amyloidosis, researchers defined serial changes in right and left heart function as well as assessed their prognostic significance in this study with cardiac amyloidosis patients with baseline and follow-up echocardiograms. Overall participants were 93, including 36 (39%) with light chain amyloidosis and 57 (61%) with transthyretin amyloidosis. Findings revealed adverse outcomes in correlation with baseline right ventricular (RV) free wall longitudinal strain (FWLS) but not in relation to changes at follow-up in this group of cardiac amyloidosis patients. There was a significant correlation of change in RV FWLS with baseline as well as follow-up alteration in left ventricular global longitudinal strain, likely indicating progressive biventricular amyloid deposition.
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