Toshimitsu O, Hiroaki S, Hirofumi T, et al. - In this investigation, researchers studied the use of PET/CT to identify extraoral primary cancers (EPCs) and determine the features of these cancers. Between January 2006 and December 2016, medical records for 891 patients with oral cancer who had PET/CT for the detection of EPCs were studied. In total, 35 EPCs were identified by PET/CT in 34 patients with primary oral carcinoma (3.8%). In the upper gastrointestinal tract, colon, lung, kidney, liver, prostate, breast, bladder, thyroid, pancreas, and hypopharynx, the extraoral lesions have been discovered. Data reported that the overall rate of survival was 64.6% and the disease-specific rate of survival was 84.8%. Findings suggested that PET/CT has been helpful to detect EPCs early. Using PET/CT to detect and treat EPCs early without symptoms can enhance the results of therapy.