Jennings E, et al. - Authors summarized current mainstream research in terms of adverse drug reaction (ADR) detection, prediction, and prevention in multi-morbid older patients. They found that in hospitalized multi-morbid, older adults, ADR could be as high as 39% and up to two-thirds of these ADRs can be considered preventable and, therefore, potentially avoidable. As there is a lack of standardized universally accepted methodology for ADR prediction, detection, causality assessment and subsequent prevention in older people, ADR prevention in multi-morbid older patients can be challenging. They recommended focusing on the culprit drugs that commonly lead to major ADRs in older multi-morbid hospitalized patients with polypharmacy. They suggested that ADR occurrence could be better predicted with the risk associated with particular drug classes than patient characteristics alone.