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Descemet stripping endothelial keratoplasty in pediatric patients with congenital hereditary endothelial dystrophy

American Journal of Ophthalmology Nov 08, 2019

Yang F, Hong J, Xiao G, et al. - Researchers assessed a retrospective case series of pediatric patients with congenital hereditary endothelial dystrophy (CHED) who underwent Descemet stripping endothelial keratoplasty (DSEK) in order to report the long-term outcomes of DSEK with suture-assisted donor lenticule insertion performed in different age groups for pediatric patients with CHED. They included 30 eyes of 16 patients: 19 eyes (10 patients) in the child group and 11 eyes (6 patients) in the infant group. The infant group exhibited better average postoperative best-corrected visual acuity (BCVA) (logMAR 0.32 ± 0.11) than that observed in the child group (logMAR 0.54 ± 0.20. Postoperative BCVA was achieved or was better than logMAR 0.4 in 33% of cases in the child group and 86% of cases in the infant group. The child group had average endothelial cell loss of 31.21% ± 9.17%. These findings suggest that in infant patients with CHED, improved visual outcomes could be achieved after DSEK without significant complications. Advocated technical points are suture-assisted donor lenticule insertion techniques, Descemet membrane stripping, and postoperative sedation.
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