Sy J, et al. - In 771 patients enrolled in the ACTIVE/ADIPOSE prevalent dialysis cohort study, researchers examined the link between frailty and depression, the risk factors for their development, and their independent associations with mortality. They assessed frailty and presence of depressive symptoms by using Fried's frailty phenotype and the Center for Epidemiologic Studies Depression score, respectively. Over time, a high prevalence of frailty and depressive symptoms was reported among dialysis patients. Frailty and depressive symptoms in these subjects showed robust associations with one another and independent relations to mortality. On multivariable logistic regression, 2.14-fold higher odds of being frail at baseline and a 2.16-fold higher odds of incident frailty during follow-up were both reported in relation to baseline depressive symptoms. In time-varying survival analysis, mortality was independently predicted by frailty and depressive symptoms.