Wen FH, Chou WC, Hou MM, et al. - Researchers performed this secondary-analysis study with the aim to determine specific depressive-symptom trajectories for caregivers of advanced cancer patients from end-of-life (EOL) caregiving through the first 2 bereavement years with closely spaced assessments. A total of 661 caregivers were assessed monthly for depressive symptoms during EOL caregiving and 1, 3, 6, 13, 18, and 24 months after loss using the Center for Epidemiologic Studies-Depression scale. Seven distinct depressive-symptom trajectories (prevalence) were identified which are characterized by the timing, intensity, and duration of depressive symptoms: minimal-impact resilience (20.4%), recovery (34.0%), preloss-grief only (21.6%), delayed symptomatic (9.1%), relief (5.9%), prolonged symptomatic (6.5%), and chronically persistent distressed (2.5%). This suggests heterogeneous responses by caregivers of advanced cancer patients to the stresses of EOL caregiving and bereavement. Closely spaced assessments linking caregivers’ psychological experiences from caregiving through bereavement can aid in more comprehensive illustration of their depressive-symptom trajectories, which validate both the wear-and-tear and relief hypotheses, and allows targeting interventions for distinct depressive-symptom trajectories.