Dillon DG, et al. - In view of the diffusion tensor imaging (DTI) studies reporting reduced fractional anisotropy (FA) in major depressive disorder (MDD), researchers planned to determine if reduced FA in depressed adults was related to individual differences in anhedonia and depressive severity. They identified a positive association of anhedonia with reduced FA and increased RD in white matter pathways that connect regions critical for value coding, representing stimulus-reward associations, and guiding value-based action selection. Thereby suggesting that a cardinal symptom of MDD—anhedonia—was lawfully linked to abnormalities in reward network connectivity.