Marín-Lahoz J, et al. - In patients with Parkinson disease (PD), researchers longitudinally assessed the role of depression in the development of impulse control disorders (ICDs). Following the Questionnaire for Impulsive-Compulsive Disorders in PD (QUIP), they included PD patients without ICD at baseline using information from the Parkinson Progression Markers Initiative (PPMI). Participants in the study were prospectively assessed first quarterly and then biannually. At baseline, 68 of 354 individuals were depressed. Median follow-up was 4.08 years. Depression at baseline was linked to higher ICD risk. Findings suggested that depression predisposes ICD in PD to develop. Dopamine agonists magnify this danger. Therefore, dopamine agonists should be used with caution in depressed patients with PD.