Kim D, Wang RD, Kiss A, et al. - Researchers examined if and how recent and/or remote depression is linked with the risk of Alzheimer dementia (AD) as well as differences in this risk between men and women. They followed older adults (age 50+) with normal cognition, who visited memory clinics across the United States between September 2005 and December 2019 until first diagnosis of AD or loss to follow up using the National Alzheimer's Coordinating Center database. AD developed in 652 of 10,739 enrolled participants over a median follow-up of 55.3 months. Observations suggest an independent association of recent (within 2 years) depression, but not of remote depression, with increased risk of incident AD. In females, but not in males, recent depression was identified as predictive of AD development, while gender did not moderate recent depression-associated risk of developing AD.