Genc D, et al. - The immunomodulatory effects of dental follicle mesenchymal stem cells (DFSCs) on CD4⁺ T helper cell responses of asthmatic patients were determined. A comparison of the results with the results obtained with asthmatic patients on immunotherapy and with healthy individuals was performed. DFSCs-induced suppression of allergen-induced Th2-cell polarization in favor of Th1 responses, as well as DFSCs-induced reduction in antigen-presenting cell co-stimulatory activities. The data also suggested that DFSC-based cell therapy offers pro-tolerogenic immunomodulation relevant to allergic diseases, such as asthma.