Shane E, Shiau S, Recker RR, et al. - Researchers in their prior work had reported a correlation of providing teriparatide with substantial increases in bone mineral density (BMD) at the lumbar spine (LS), total hip (TH) and femoral neck (FN) and small declines at the distal radius (DR) in 41 premenopausal women with idiopathic osteoporosis (IOP), all severely affected with low trauma fractures and/or very low BMD. This is a preplanned phase 2B extension study conducted to determine the effects of teriparatide dissipate if not followed by antiresorptives.

• After completing teriparatide, 32 premenopausal women with IOP were provided denosumab for 12M and 29 for 24M.

• The participants showed statistically significant increases in BMD at the LS, TH and FN.

• Overall findings suggest that premenopausal women with severe osteoporosis may exhibit an increase in BMD after receiving teriparatide and denosumab sequentially.