Lawrence JM, Reynolds K, Saydah SH, et al. - Among youth and young adults (YYAs) with youth-onset diabetes, findings revealed excess mortality for each type of diabetes with differences in risk related to diabetes type, age, race/ethnicity, and gender.

• This analysis included 19,717 YYAs newly diagnosed with diabetes before 20 years of age; 14,721 with type 1; 4,141 type 2; and 551 secondary and 304 other/unknown diabetes type.

• A median follow-up 8.5 years revealed deaths of 283 persons: 133 with type 1, 55 with type 2, 87 with secondary, and 8 with other/unknown diabetes type.

• For the first three groups, standardized mortality ratios (SMRs) (95% CI) were estimated to be 1.5 (1.2–1.8), 2.3 (1.7–3.0), and 28.0 (22.4–34.6), respectively.

• The underlying reason for death was diabetes for 42.1%, 9.1%, and 4.6% of deaths, respectively.

• A greater SMR was reported for type 2 vs for type 1 diabetes.

• Significantly higher SMRs were noted for persons with type 1 diabetes who were <20 years of age, non-Hispanic White and Hispanic, and female as well as for those with type 2 diabetes who were <25 years of age, from all race/ethnic minority groups, and from both genders.