Cudejko T, et al. - An analysis, which was the first study, of data for 44 subjects with knee osteoarthritis (OA) who were enrolled in a laboratory-based trial assessing the impact of wearing a commercially available soft knee brace (elastic, nonadhesive orthoses which are frequently used to diminish activity limitations in patients with knee OA) was conducted by the researchers in order to judge whether improvement of proprioception, pain, or dynamic knee instability mediated the effect of wearing a soft knee brace on activity limitations in subjects who had knee OA. Via the 10-meter walk test and the Get-Up and Go test, activity limitations were analyzed. A reduction in pain (scored on a numeric rating scale) and a reduction in dynamic knee instability mediated the impact of wearing a soft knee brace on the decrease of activity limitations, while alterations in proprioception and pressure pain threshold did not mediate this impact. Hence, reduced pain and diminished dynamic knee instability were concluded as the pathways by which wearing a soft knee brace reduced the activity limitations in subjects with knee OA.