Monti LD, et al. - Experts aspired to decide whether L-arginine supplementation lasting for 18 months maintained long-lasting effects on diabetes incidence, insulin secretion and sensitivity, oxidative stress, and endothelial function during 108 months among subjects at high risk of developing type 2 diabetes. The outcomes recommended that the administration of L-arginine could delay the development of T2DM for a long period. In some extent, this effect could be mediated by L-arginine-induced reduction in oxidative stress.