Otaki Y, et al. - In this study with 154 patients, researchers assessed how specific components of noncalcified plaque (NCP) were influenced by low-density lipoprotein cholesterol (LDL-C) reduction. There were 154 participants who had baseline LDL-C≥70 mg/dl and were undergoing serial coronary CT angiographies (CTAs) (118 men, 60 ± 10 years, interval 4 ± 2 years). They used semi-automated software to quantify plaque components on the basis of CT reduction in Hounsfield units: 30-75, low attenuation plaque; 76–130, medium-low attenuation plaque; 131–350, medium attenuation plaque; >350, calcified plaque. They defined LDL-C reduction as a decrease >10% of baseline LDL-C. Findings revealed a link between LDL-C reduction and attenuation in all components of NCP measured by quantitative CTA. For evaluating changes over time in coronary plaque on CTA, the optimal measurement may be alteration in total NCP volume.