Janmaat CJ, et al. - Researchers compared the kidney function decline during pre-dialysis in chronic kidney disease (CKD) patients, in CKD 3–5 cohorts or dialysis-based studies through a systematic review and meta-analysis. PubMed, EMBASE, Web of Science and Cochrane were searched to identify eligible studies reporting an estimated glomerular filtration rate (eGFR) decline (mL/min/1.73 m²) in adult pre-dialysis CKD patients. As compared to CKD 3–5 cohorts, dialysis-based studies report faster mean annual eGFR decline during pre-dialysis. The findings suggested that eGFR decline data from CKD 3–5 cohorts ought to be utilized to guide clinical decision making in CKD patients and for power calculations in randomized controlled trials with CKD progression during pre-dialysis as the outcome.