Master H, Thoma LM, Neogi T, et al. - This prospective, longitudinal, and multicenter observational study was undertaken to assess the relationship of the volume and intensity of daily walking at baseline with the risk of knee replacement (KR) over five years among adults suffering from advanced structural knee osteoarthritis (OA). From four sites in the United States, participants were recruited. There were 516 adults with advanced structural disease ([mean±sd] age: 67.7±8.6 years), of which 88 (17%) underwent a KR over five years. A decrease in the risk of KR incidence by 35% and 37% was observed in relation to statistically replacing 10 minutes/day of very-light and light walking with 10 minutes/day of moderate walking, respectively. Findings showed that no increase in KR risk, over five year, was brought about by daily walking volume and intensity, and rather these may exert a protective effect in some cases in adults with advanced structural knee OA.