Bharmal SH, Kimita W, Ko J, et al. - Increased levels of interleukin-1β and interferon γ in acute pancreatitis patients with normoglycemia at baseline could be predictive of progression to new-onset prediabetes after acute pancreatitis (NOPAP) during follow-up.

• This is a prospective longitudinal cohort study (as part of the LACERTA project) of 68 persons with non-necrotizing acute pancreatitis who had no diabetes mellitus.

• Progression to NOPAP was significantly predicted by interleukin-1β and interferon γ, with odds ratio of 1.097 and 1.094, respectively (post- accounting for age, gender, body mass index, and etiology of acute pancreatitis).

• Of the studied cytokines/chemokines, none demonstrated statistically significant links with the antecedent prediabetes group (post- accounting for the above covariates).