Sushama S, et al. - In subjects with localized vitiligo and generalized vitiligo, the serum levels of cytokines secreted by Th1 (IL-2, TNF-α), Th2 (IL-6), and Th17 cells (IL-17, IL-22) were evaluated. Experts also correlated their levels with the extent, duration, and activity of the disease. An important role in the maintenance and spread of vitiligo was played by the cytokines secreted by Th17 cells as they increase in line with the extent of disease. With the activity of disease, TNF-α increased proportionaly, therefore could act as a biomarker for identifying the subjects having aggressive disease.