Chadwick HK, Abbott J, Hurley MA, et al. - This study was carried out to assess cystic fibrosis-related diabetes (CFRD) as a mechanism for cognitive impairment in people with cystic fibrosis (CF). It was hypothesised that cognition would be poorer in adults with CFRD than in those with CF without diabetes (CFND) or in healthy controls. Researchers evaluated cognitive performance using the Cambridge Neuropsychological Test Automated Battery which provides a comprehensive cognitive assessment with tests mapping onto specific brain regions. They recorded CF specific clinical variables for the two CF groups. They recruited a total of 98 people with CF (49CFRD,49CFND) and 49 healthy controls. The results showed that managing CF requires higher order executive function. It has been considered that impairments may be sufficient to interfere with self-care and the ability to conduct everyday tasks efficiently. Moreover, at which point in the CF disease trajectory these difficulties begin, and what may attenuate them, has yet to be ascertained.