Zouboulis CC, et al. - Researchers conducted this prospective randomized study to detect the effectiveness and safety of cryosurgery regimens on keloids and the occurring biological changes caused by the treatment. They compared the effectiveness and tolerability as well as histological/immunohistochemical impacts of liquid nitrogen contact cryosurgery as a single regimen (group A) and combined with intralesional corticosteroids (group B) on young (<2 years old), small (≤ 10 cm²) keloids in 40 patients (2-sided effect, α-error 1%, power 95%). Findings suggested that not only as a destructive physical procedure but also by inducing biochemical and immunological scar rejuvenation, cryosurgery without and with intralesional corticosteroids is effective and safe on young, small keloids.