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Cross-sectional associations of sex hormones with leucocyte telomere length, a marker of biological age, in a community-based cohort of older men

Clinical Endocrinology Jan 24, 2019

Yeap BB, et al. - Using cross-sectional data from 2913 men (aged 76.7 ± 3.2 years), researchers studied the association of testosterone (T) and its bioactive metabolites, dihydrotestosterone (DHT) and oestradiol (E2) with telomere length and clarified sex hormone associations with leucocyte telomere length (LTL) in a community-based cohort of older men. In older men, T and DHT are not correlated with LTL, while E2 is independently related to LTL and sex hormone-binding globulin (SHBG) is inversely linked, resulting in lower biological age sex hormone exposure.
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