Li J, Li X, He F, et al. - Given that psoriasis is a common chronic autoimmune skin disease, with T cells playing a predominant role in its pathogenesis, researchers conducted this cross‐sectional study to examine the relation of T‐cell repertoires (TCR) and major histocompatibility complex (MHC) in psoriatic patients to further understand mechanisms in disease pathogenesis. They involved nine pairs of monozygotic twins with inconsistent psoriasis and investigated the TCR diversity and MHC haplotype of the individuals utilizing multiple‐PCR and high‐throughput sequencing. In addition, 665 psoriatic individuals were applied to validate the relation of human leucocyte antigen (HLA) class I allele HLA‐C *07:02 and early onset or lesion severity of psoriasis. Findings suggested that HLA‐C *07:02 is positively linked to the diversity of TCRV gene in psoriasis and maybe a potential biomarker of early-onset/severe lesions of psoriasis.