Tucker JS, D’Amico EJ, Pedersen ER, et al. - Information on COVID-19 vaccination and attitudes among young adults with recent experiences of homelessness has been provided in this study.

• From a clinical trial of a risk reduction program for youth experiencing homelessness in Los Angeles, 134 participants were surveyed about COVID-19 vaccinations.

• Among respondents, 29% were vaccinated and 50% did not show their interest in getting vaccinated.

• Among the unvaccinated, vaccine was offered to 58%; further, 38%-45% had strong distrust of the vaccine and worried about its harmfulness.

• Relative to the general US population, young adults with recent experiences of homelessness reported lower vaccination rates.

• These findings highlight the necessity for greater direct outreach that includes both offering the vaccine and addressing misconceptions about its safety to raise vaccination rates in this population.