COVID-19 pulmonary pathology: A multi-institutional autopsy cohort from Italy and New York city
Modern Pathology Sep 07, 2020
Borczuk AC, Salvatore SP, Seshan SV, et al. - In this study, the lungs of 68 autopsies from 3 institutions in heavily hit areas (2 USA, 1 Italy) were systematically analyzed. Researchers conducted a detailed assessment of several compartments (airways, alveolar walls, airspaces, and vasculature) to ascertain the range of histologic features. A 47 males and 21 females with a median age of 73 years (range 30–96) were included in the cohort. The data revealed that the pulmonary vasculature, with capillary microthrombi and inflammation, as well as macrothrombi, are commonly involved. In areas of ongoing active injury, Viral infection contributes to persistent and temporally heterogeneous lung damage.
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