Fernandes S, Were V, Gutman J, et al. - For prevention of malarial infection during pregnancy in HIV-negative women, long-lasting insecticidal nets together with intermittent preventive treatment in pregnancy with sulfadoxine–pyrimethamine (IPTp-SP) are currently relied upon. In view of the increasing sulfadoxine–pyrimethamine resistance in Africa, researchers here examined the cost-effectiveness of intermittent preventive treatment in pregnancy with dihydroartemisinin–piperaquine (IPTp-DP), which is a promising candidate, vs IPTp-SP to prevent clinical malaria infection (and its sequelae) during pregnancy. Cost-effectiveness analysis was performed employing meta-analysis and individual trial results from three clinical trials conducted in Kenya and Uganda. Findings support the cost-effectiveness of IPTp-DP among HIV-negative pregnant women with high uptake of long-lasting insecticidal nets in regions with high malaria transmission and high sulfadoxine–pyrimethamine resistance. A comprehensive overview of the current evidence on the cost-effectiveness of IPTp-DP was provided in this work.