Huang L, et al. - A comparative scrutiny was performed of the cost-effectiveness of 2 common 'noninvasive' modes of respiratory support (continuous positive airway pressure (CPAP) vs high-flow with 'rescue' CPAP backup and high-flow without rescue CPAP backup) for infants born preterm with respiratory distress. CPAP as sole primary support exhibited a greater likelihood of being cost-effective compared with high flow. It was deduced that the neonatal units choosing to use only one device ought to apply CPAP as primary respiratory support. Moreover, CPAP was unlikely to be cost-effective if the willingness to pay per ventilation avoided was less than A$179000 (US$123000) compared with high-flow with rescue CPAP backup.