Yang S, et al. - The diagnostic significance of clinically well-accepted audiological tests in indicating endolymphatic hydrops (EH) in Meniere's disease (MD) was reassessed during this study. In all of the MD patients, 3-dimensional fluid-attenuated inversion recovery magnetic resonance imaging demonstrated EH in either the vestibule or cochlea to various degrees, 24 hours after intratympanic gadolinium chelate injection. Vestibular and cochlear EH were seen to be significantly associated with PTA threshold. Data demonstrated that disrupted ionic homeostasis in the inner ear, but not the EH, could serve as a contributory factor to changes in the negative summating potential/action potential (-SP/AP) ratio.