Zhu C, Gu L, Liu Z, et al. - Researchers focused on clarifying the correlation between vascular endothelial growth factor (VEGF) signaling pathway and tumor immune microenvironment in patients suffering from head and neck squamous cell carcinoma (HNSCC). From the The Cancer Genome Atlas database, they obtained RNA sequencing and clinical data of HNSCC patients. They found positive correlation of VEGF signaling pathway with immune cell infiltration, immune-related gene expression profiles, and the prognosis of HNSCC patients. They inferred that in HNSCC cases, encouraging benefits may be achieved by combining anti-VEGF signaling pathway agents with immunotherapy, such as immune checkpoint inhibitors therapy.